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Furthermore, we measured the mRNA levels of Nrf2 and its downstream target HO-1 by RT-qPCR (Figure 5B)

248 Diabetic rats show significantly increased ROS content, decreased GPX4 expression, a decreased GSH/GSSG ratio, and significant retinal tissue damage and ferroptosis, which could be inhibited by ferroptosis inhibitor Fer-1

Several mechanisms explain why GLP-1 RAs reduce body weight: Central appetite suppression: GLP-1 receptors in the hypothalamus and brainstem alter hunger signalling and food reward

Enzyme reactions in a membrane model

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But the practical application requires understanding typical dosing ranges and their implications