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NICE typically recommends considering these agents when metformin alone proves insufficient, alongside SGLT2 inhibitors as key options for treatment intensification

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NAC treatment also reduced, in arterial cord blood, citrulline/arginine ratio ( P 0.03, regardless of IPTB severity) and taurine/cysteine ratio ( P 0.04, mainly in moderate IPTB cases), reflecting NO-synthase activity and oxidative cysteine catabolism, respectively (Fig