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demonstrated that selenium supplementation decreased histone H4 acetylation at K12 and K16 in the COX-2 and TNF - promoters and of the p65 subunit of the redox-sensitive transcription factor nuclear factor kappa B in primary and immortalized macrophages, indicating the critical role of selenoprotein in inhibiting histone H4 acetylation (99)

Additionally, there is presently no approved pharmaceutical medication to prevent or delay the formation of cataracts [31, 32]

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