Bestatin DEVD-FMK N-dimethyl-2

N-dimethyl-2

Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind

3-dihydro-1H-indol-1-yl]methyl}benzoic acid

10 mM abolishes ABCG2 activity

InChi: InChI=1S/C29H26N2O4/c1-3-34-28(32)25-9-7-22(8-10-25)23-11-13-27(14-12-23)35-29(33)31(2)20-21-5-4-6-26(19-21)24-15-17-30-18-16-24/h4-19H

Bestatin DEVD-FMK N-dimethyl-2Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer