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[21] [22] [23] [24] [25] Anemia may present with a number of further common symptoms, [21] [26] including hair thinning and loss, early greying of the hair, mouth ulcers, bleeding gums, [22] angular cheilitis, a look of exhaustion with pale and dehydrated or cracked lips and dark circles around the eyes, as well as brittle nails

This period establishes the gene expression changes that drive collagen synthesis, inflammation reduction, and tissue remodeling

Consequently, the biological functions of vitamin D depend on the modulation of the VDR for its genomic effects and membrane-associated proteins for its nongenomic effects including various signaling pathways (135)

Guryanova, S.V

It improves reticuloendothelium function

Without angiogenesis, repair cells cannot reach the damage site and nutrients cannot feed new tissue growth