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271 , C495C503 (1996)

Step 2: Add Targeted Anti-Inflammatory and Antioxidant Support Once a foundation is in placeor if inflammation and pain remain prominentadditional support may be layered in based on symptoms: Turmeric (curcumin) to further downregulate inflammatory pathways and immune activation Adaptogens (such as those found in Adrenal Support) to improve stress resilience, support cortisol regulation, and reduce stress-triggered symptom flares Additional antioxidants if labs or symptoms suggest elevated oxidative stress These supplements are best added gradually, allowing time to assess tolerance and symptom response

Establishing a multi-dimensional biomarker system encompassing ferroptosis-related molecules, TME-immune indicators, and non-coding RNA signatures will enable precise patient stratification

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