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Ongoing clinical trials investigating strategies to improve anti-ErbB2 mAb therapy, such as ex vivo activated allogenic NK cells or macrophages engineered to express an anti-ErbB2 chimeric antigen receptor (CAR-M), may benefit from the enhanced anti-tumor immune responses induced by Cpt1a inhibition, potentially improving outcomes for tumors evading ADCC and resistant to Trastuzumab 87,88