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Combination focus: Much of its regulatory development is tied to dual-therapy use with GLP-1 drugs, positioning it as a combination obesity therapy rather than a standalone peptide

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Elevated expression of the glutamate transporter subunits GLAST and GLT1 was also found in the cerebral cortex and striatum of adult Gcdh -/- mice, whereas in infant mice only GLAST mRNA levels were augmented in the striatum

This is less commonly observed with Tirzepatide, which lacks glucagon activity

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Some drugs suppress REM sleep initially, and when discontinued or when the body adapts, a "REM rebound" phenomenon can occur, leading to more intense or frequent dreams