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FDA www.accessdata.fda.gov/drugsatfda_docs/nda/2005/21-332_Symlin%20Injection_prntlbl.pdf (2005)

Sub-therapeutic dosing may produce no noticeable effects, positive or negative

Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, compared to semaglutide (GLP-1 only) and tirzepatide (GLP-1 and GIP)