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Certain nutrients have been found to be activators of important metabolic pathways involved in PCOS, such as insulin resistance hyperlipidemia, oxidative stress, and inflammation, thus providing some possible medical means for treating the condition [65]

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As a glutamine transporter induced by oxygen deprivation in breast cancer, the upregulation of SLC38A2 results in resistance to hormone therapy and subsequently a poorer prognosis [72]

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In the context of the Melanotan-1 pathway, this genotype may indicate a less responsive melanocortin signaling environment, where peptide-driven stimulation of melanin production may be somewhat attenuated

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