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High-priority methodological tasks include: (i) Utilizing real-world cohorts to evaluate the strategic effects of initiation timingregime durationwashout window on long-term metabolic and reproductive outcomes

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Supporting this hypothesis, studies have demonstrated that in individuals with increased intestinal permeability, opioid peptides derived from gluten and casein can enter systemic circulation and potentially enhance opioid activity in the brain (Cass et al