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Although certain side effects have been reported more commonly with semaglutide than with tirzepatide, trial data suggest that such differences may be a reflection of variation in background (i.e., placebo group) rates in the enrolled trial populations, with the proportional increase in many side effects when compared to placebo being similar for the 2 agents (Table 2)

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Participants receiving the 2.4 mg weekly dose experienced average weight loss of 14-18% of their body weight over 68 weeks, compared to 2-3% with placebo

Pharmaceutical Research (1999) 3

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