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Despite this limitation, OS was shown to be involved in many aspects of female reproduction (122124)

This shift in metabolic preferences has been further validated in specific cell lines, such as A549 and H1299, where SLC7A11 knockdown led to an increase in OXPHOS and a decrease in glycolysis ( in vivo , within a tumor microenvironment, where the metabolic reprogramming associated with altered SLC7A11 expression was evident (61)

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Patient monitoring should include: Baseline lipid panel, hemoglobin A1c, and liver function tests Blood pressure monitoring (GLP-1 agents typically reduce systolic BP by 3-5 mmHg) [10] Assessment for gastrointestinal adverse effects during dose titration Evaluation for contraindications (personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2) [1] [3] Monitoring for gallbladder disease (increased risk with rapid weight loss) In patients with diabetes and retinopathy, monitoring for worsening eye symptoms, particularly with rapid glycemic improvement Renal function assessment, especially if severe gastrointestinal symptoms cause dehydration Patients should seek immediate medical attention for severe abdominal pain, which may indicate pancreatitisa rare but serious adverse effect

Jain AB, Kanters S, Khurana R, Kissock J, Severin N, Stafford S