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IGF-1 globally suppresses immune and cytokine signaling pathways Transcriptomic profiling revealed that IGF-1 downregulated cytokine signaling, antigen processing and presentation, and interferon-responsive pathways across all models

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3.1.2 Ruxolitinib Ruxolitinib, the first Jakinib to get FDA approval, is a JAK1/2 inhibitor designed to deal with polycythemia vera and intermediate- and high-risk primary myelofibrosis (33)

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Glutathione and GSH levels were correlated, suggesting that glutathione may be substituted with GSH

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