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Severe congenital disabilities can occur with Accutane usage during pregnancy, including: Hearing and visual impairment Missing or malformed earlobes Brain function abnormalities Facial dysmorphisms, such as small or missing eyes or a cleft palate Congenital heart defects Hydrocephalus (fluid and pressure buildup on the brain) Any patient who can become pregnant must use two effective forms of birth control during treatment or commit to abstinence

It is essential for the transport of long-chain fatty acids from the cytoplasm into the mitochondria, where they are oxidized to produce energy

Research has also shown that neuronal death, neurodegeneration, decreased neurogenesis, and reduced neuroplasticity can jointly contribute to impaired neuro-progression (70)

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