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However, it remains uncertain whether these changes result from direct anti-inflammatory effects of GLP-1 receptor activation or are secondary to weight loss and improved metabolic health

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Disclosure The author reports no conflicts of interest in this work

The new 32-week study was conducted in more than 100 adults living with HIV who had excess fat due to a condition called lipohypertrophy, which is common in people who receive injections and develops due to inflammation, and some who also had metabolic dysfunction-associated steatotic liver disease, another condition that HIV patients regularly contract

The highest levels are seen in the portal vein, after intestinal administration of the formulated peptide, while in the peripheral bloodstream similar levels are observed for both routes of administration