AAE-581 - CAS# 354813-19-7 Catalog No.:M60434-10S Brain-penetrant LSD1 inhibitors can block

Brain-penetrant LSD1 inhibitors can block memory consolidation

3H)-pyrimidinedione

WS3 was used at 25 nM concentration in RPE cells expansion assays

Chemical Name: 3-(3-(cyclopentylthio)-5-(((2-methyl-4'-(methylsulfonyl)-[1

2-PMPA at 250 mg/kg

AAE-581 - CAS# 354813-19-7 Catalog No.:M60434-10S Brain-penetrant LSD1 inhibitors can blockBalicatib(AAE 581), CAS No. 354813 19 7, is a potent and selective inhibitor of cathepsin K; 10 100 fold more potent in cell based enzyme occupancy assays than against cathepsin B, L, and S. IC50 value: Target: cathepsin K The cathepsin K inhibitor AAE 581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage