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Availability of data and materials Data used in the discussion were found in peer-reviewed journals and previously published case reports

Proliferating cells in culture are highly dependent on glutamine, as it is both a key nitrogen donor and carbon supply for the TCA cycle

Glutathione helps "protect" nitric oxide by neutralizing superoxide

H.et al (2024b)

CD38 has immunomodulatory effects that are dependent or independent on its NADase activity

During this process, cells will produce an imbalance between reactive oxygen species (ROS) generation and the antioxidant defense system, thereby triggering oxidative stress and ultimately leading to kidney damage