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doi: 10.1007/978-1-4419-8216-2_7 498 ManianFA

NRF2 acetylation represents a key post-translational modification, characterized by the addition of acetyl groups (CH3CO-) to specific lysine residues on the NRF2 protein within the cell

This chronic, systemic depletion allows environmental toxins and latent, dormant infections (such as EBV or human herpesviruses) to reactivate and accumulate, continuously driving immune dysfunction, mast cell activation syndrome (MCAS), and unrelenting fatigue

suggested that HQ is a tyrosinase substrate with a poor activity due to the inability to transform met -tyrosinase to oxy -tyrosinase on its own 26

This becomes particularly important for athletes following rigorous training schedules or participating in multi-day events

As mentioned earlier in this guide, the benefits of urolithin A are mainly attributed to its potential to kickstart mitochondrial autophagy or mitophagy the process of your body clearing out old, dysfunctional mitochondria and replacing them with new, healthy ones.7 8 14 When dysfunctional mitochondria build up, the production of oxidative stress in the body may increase.8 This, in turn, increases the risk of developing various chronic and degenerative diseases, such as cancer, heart disease, kidney disease, Alzheimers disease, Parkinsons disease, rheumatoid arthritis, and more.15 Besides increasing your disease risk, excess oxidative stress can also lead to: More visible signs of skin aging (fine lines, wrinkles, etc.)15 Increased muscle atrophy26 Reduced muscle force generation26 Neuroinflammation27 Since urolithin A has the potential to help your body clean out dysfunctional mitochondria by supporting mitophagy, it may also be able to lower your risk of health concerns attributed to oxidative stress increasing your healthspan and, possibly, your lifespan