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Arch Gen Psychiatry 51 : 199214

Protocol 2: significant weight loss (20-25% body weight) Goal: Substantial weight reduction for health improvement Tirzepatide approach: Full escalation to 10-15 mg Expect to reach target dose by week 17-21 Weight loss at 15 mg: approximately 22.5% at 72 weeks Plateau typically occurs around weeks 60-72 Retatrutide approach: Full escalation to 8-12 mg Expect to reach target dose by week 13-17 Weight loss at 12 mg: 24.2% at 48 weeks, 28.7% at 68 weeks No plateau observed in trial data at 48 or 68 weeks For significant weight loss goals, retatrutide reaches 20%+ body weight reduction faster and ultimately achieves a higher ceiling

J Biol Chem 262(35):172311739

User feedback suggests it helps improve dullness caused by staying up late, though results for stubborn dark spots may be slower to appear

GHRP-2 was reported to lead to a 47-fold increase in pulsatile GH secretion, while GHRH-mimetics appear to lead to only a 20-fold increase

Microglia coordinate cellular interactions during spinal cord repair in mice