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Clinical Evidence and Efficacy Outcomes Real-world evidence demonstrates that metformin-semaglutide combinations are effective across multiple trials

10.1111/jgs.13644 25 BolducV.Thorin-TrescasesN.ThorinE

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While a direct comparison is hard (due to differences in study designs), it seems that tirzepatide is a better overall drug for weight loss (and also shows greater reduction in A1C)

The trial results highlight the potential for patients taking GLP-1 drugs to lose too much weight, which could produce side effects and health problems that must be balanced against any benefits of weight loss, Dr