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The clinical data suggesting a possible association come from post-marketing surveillance data that have substantial risk for bias and do not control for important confounding variables

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Despite the ever-growing list of FDA-approved drugs, the success of anti-angiogenic therapy has so far been quite limited, only providing short-term relief from tumor growth before resistance occurs and typically resulting in modest survival benefits

Conversely, isoniazid and pyrazinamide (tuberculosis drugs) are structural analogs of niacin that can interfere with niacin metabolism, potentially precipitating pellagra in rare cases

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Wegovys approval for fatty liver, for instance, has opened a new pathway