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This can happen when the body is adjusting to the medication

Thus, the presence of oxygen lends this approach suitable selectivity for antibiotic applications without distinct human cytotoxicity 24

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In addition, certain ART drugs, especially early nucleoside reverse transcriptase inhibitors, inhibit polymerase , driving mtDNA depletion and mutation accumulation that underlie toxicities such as lipodystrophy, neuropathy, and accelerated aging