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Lancet (2021) 398:26276

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The study, which was a trial extension and tracked 327 people, showed that the 228 participants who stopped taking semaglutide regained a mean of two-thirds of their prior weight loss within a year

In that way, headache improvement might not only be a consequence of weight loss but also another direct effect of GLP-1-RAs on intracranial pressure [15], which seems to be directly associated with MHD and headache severity [30]

Jasmine Gomez is the lifestyle and commerce editor at Womens Health, where she tests and writes about the best products across home, sleep, travel, and more