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Key Takeaways Glutathione acts as the body's master antioxidant, crucial for detoxification and maintaining cellular health

AOD 9604 AOD-9604 is a synthetic peptide derived from a modified fragment of human growth hormone (HGH), specifically the C-terminal 15amino-acid region (with an additional amino acid added for stability)

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single administration, 9th day), group 3 (MTX + ALEAP (500 mg/kg

In vivo, the regulation of antioxidant pathways (NF-B, Keap1-Nrf2-ARE, mitogen-activated protein kinase, and so on) is signaled by ROS, and plant protein-derived peptides can regulate these signaling pathways (Lv et al., 2022)

Classification of these pathways according to the involved pathological process revealed a broad division into inflammation-related pathways (chemokine signaling, cytokine-cytokine receptor interaction, MAPK signaling, Toll-like receptor signaling, NOD-like receptor signaling, NF-B signaling, etc.), metabolism-related pathways (phagosome, PI3K-AKT signaling, etc.), and fibrosis-related pathways (ECM-receptor interaction) (Figure 7C)