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Compared to endogenous GLP-1 and glucagon, retatrutide demonstrates lower potency at GLP-1 and glucagon receptors but substantially higher potency at the human GIP receptor a pharmacological profile deliberately engineered to balance efficacy with tolerability

Additionally, symptoms of dehydration from gastrointestinal effectssuch as dizziness, reduced urination, or extreme thirstrequire prompt medical attention

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Rybelsus remained commercially relevant because it gave the semaglutide weight management drug industry an established oral brand, even though its United States sales slowed as prescriber preference shifted toward once-weekly GLP-1 options and obesity-focused positioning