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Hormonal changes influence insulin sensitivity, which in turn affects how the body responds to GLP-1 medications

The mechanism behind this side effect is linked to the slowing of gastric emptying and changes in gut motility, which can lead to discomfort and a sense of fullness

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As a result, the C 8 fatty acid chain of the octanoyl moiety sits on top of an extensive polar interaction network at the bottom of the cavity II including E124 3.33 and R283 6.55 while being capped by hydrophobic GHSR residues from the upper region of the cavity II (Fig

doi: 10.3389/fnagi.2024.1455858 Received 27 June 2024 Accepted 19 September 2024 Published 02 October 2024 Volume 16 - 2024 Edited by Kimberly Stieglitz, Roxbury Community College, United States Reviewed by Fawad Khan, Ochsner Health System, United States Faten Mohamed Ibrahim, National Research Centre, Egypt Updates Copyright 2024 Chen, Meng and Ko

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