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[64], which involved a co-culture of primary astrocytes with the bEnd.3 endothelial cell line, incubation with exendin-4 reduced the levels of the astrocyte-derived vascular endothelial growth factor (VEGF-A), matrix metalloproteinase-9 (MMP-9), chemokine monocyte chemoattractant protein-1 (MCP-1), and the chemokine C-X-C motif ligand 1 (CXCL-1), induced by oxygenglucose deprivation (OGD), and subsequently led to the increased expression of tight junction proteins in the bEnd.3 cells

In November 2025, the administration announced deals with Eli Lilly and Novo Nordisk to provide their GLP-1s at reduced prices

In Vitro In Vivo [1]

Of the preclinical studies examined, 22 showed a reduction in amyloid-beta plaques, and 19 showed a reduction in tau tangles