Human Acid Sphingomyelinase-like Phosphodiesterase 3B, SMPDL3B ELISA Kit , 96T Bottle-Top Dispenser It is an imprinted gene|

It is an imprinted gene| expressed only from the paternal allele| and epigenetic changes at this locus are associated with Wilms tumour| Beckwith-Wiedemann syndrome| rhabdomyosarcoma| and Silver-Russell syndrome

Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2

Expression of ITGA3 may be correlated with breast cancer metastasis

reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2

and liver parenchymal cells to all proliferating cells in the body

Human Acid Sphingomyelinase-like Phosphodiesterase 3B, SMPDL3B ELISA Kit , 96T Bottle-Top Dispenser It is an imprinted gene|Lipid modulating phosphodiesterase (PubMed: 26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed: 26095358). Lacks activity with phosphocholine containing lipids, but can cleave CDP choline, and