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The FDA has approved these weight management agents for adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity such as hypertension, type 2 diabetes, or dyslipidemia

The December 2024 FDA advisory committee cited insufficient safety data for the injectable route as one reason for declining to approve compounding

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Ozempic, Wegovy, and Rybelsus all contain the same active ingredient: semaglutide, a GLP-1 agonist

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Efficacy and safety of glucagon-like peptide-1 receptor agonists for weight loss among adults without diabetes: a systematic review of randomized controlled trials