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This process is an outcome of TGF-1, vascular endothelial growth factor (VEGF), IL-6 and IL-8 secretion by platelets and macrophages, as well as endometriotic production of PAI-1, and changes in the expression of MMPs and tissue inhibitors of MMPs which together, with local nerve fibers, participates to EMT, fibroblast to myofibroblast transformation (FMT), and smooth muscle metaplasia (SMM) [53, 57] (Fig

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The use of IMCIVREE in pediatric patients aged 2 to less than 6 years with weight less than 20 kg and severe renal impairment is not recommended [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]

We don't just look at symptoms, we look at the big picture