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GLP-1 agonists and gastrointestinal adverse events
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Dynamin-related protein 1 (Drp1) phosphorylation increases 3.1-fold, promoting excessive mitochondrial fission and compromising sperm motility ( 3.3.2 Energy metabolism impairment 3.3.2.1 Electron transport chain dysfunction EED exposure severely compromises mitochondrial energy production through direct effects on the electron transport chain

Contact your GP, trial coordinator, or a healthcare professional promptly but without the urgency of 999 if you experience: A widespread or rapidly spreading rash, particularly if accompanied by fever, joint pain, or malaise Blistering, peeling, or open sores on the skin, which may indicate a more serious dermatological reaction Persistent or worsening injection site reactions that do not resolve within a few days Skin changes accompanied by systemic symptoms such as fatigue, fever, or lymph node swelling Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome or toxic epidermal necrolysis, are rare but serious drug-related skin conditions requiring emergency assessment

These include: Dulaglutide: Prescribed as Trulicity for type 2 diabetes (there is no dulaglutide approved for weight management) Semaglutide: Prescribed as Ozempic or Rybelsus for type 2 diabetes and Wegovy for weight management Tirzepatide: Prescribed as Mounjaro for type 2 diabetes and Zepbound for weight management There are also alternatives to GLP-1s, including prescription weight-loss pills like naltrexone/bupoprion and Qsymia, both of which decrease your appetite