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This suggests very little of it actually reaches the brain

There will certainly be many arguments among experts as to whether this study met a minimum threshold for neuroprotection (preventing brain cells from dying), and my personal opinion would be a cautious MAYBE . The assessment of neuroprotection does not in general have a specific accepted and associated metric (way to measure it), so neuroprotection is largely based on the interpretation of scientists and clinicians

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Conversely, CO-GHD patients tend to be less insulin-resistant than AO-GHD patients (84), and their IGF-I levels are generally lower than their AO-GHD counterparts due to relatively lower intra-portal insulin levels

Itll help you make informed decisions with your doctor or healthcare provider