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It has been reported that Glutathione reduces melanin production by suppressing the activity of Tyrosinase and switching the eumelanin synthesis to pheomelanin synthesis

CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation

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Furthermore, we analysed clusters of genes differentially expressed in high versus low steatotic livers together with genes found in literature 19,23 and genome-wide association studies 3 (Fig