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GHK-Cu operates through multiple mechanisms: Gene expression modulation : Regulates over 4,000 human genes, including upregulation of collagen, elastin, and decorin synthesis, and downregulation of inflammatory and tissue-destructive genes Copper delivery : The copper ion is essential for lysyl oxidase (collagen cross-linking), superoxide dismutase (antioxidant defense), and cytochrome c oxidase (cellular energy) Growth factor stimulation : Increases production of FGF, VEGF, and other growth factors involved in tissue repair Glycosaminoglycan synthesis : Stimulates production of proteoglycans and glycosaminoglycans for skin hydration and structure Anti-inflammatory activity : Suppresses inflammatory cytokines including IL-6 and TNF-alpha Matrixyl# Matrixyl (pal-KTTKS, palmitoyl pentapeptide-4) is a synthetic peptide consisting of five amino acids (Lys-Thr-Thr-Lys-Ser) conjugated to a palmitic acid chain

doi: 10.1038/s43018-023-00715-8 9 LinYDongYLiuWFanXSunY

doi: 10.1111/j.1521-0391.2014.12147.x

Epigenetics Chromatin 14 , 17 (2021)

A., Sauchi, Y., & Ito, H

While eating fruit is excellent for general health, the digestive system's tendency to break down peptides means that very little intact glutathione reaches your systemic circulation