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It negatively affects the tumor microenvironment by reducing cytolytic activity, impairing dendritic cell (DC) function, and weakening the major histocompatibility complex (MHC I) signature, all of which contribute to decreased antitumor immune response (59)

[2] Age and overall health status also play important roles

showed that HMB supplementation increased lean body mass regardless of vitamin D status, strength improvements only occurred in participants with sufficient vitamin D levels (30 ng/mL)

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