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And the data is catching up to that reality

Increase of fat oxidation and weight loss in obese mice caused by a synthetic GH fragment, AOD9604

Rather than copying the peptide structure of the natural GLP-1 hormone, it uses a chemically engineered small molecule capable of activating the same receptor

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Indeed, GLP-1R knockout mice do not develop obesity [73] although postembryonic deletion of GLP-1Rs in the paraventricular nucleus of the hypothalamus (PVH) leads to weight gain due to increased food intake [72]