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Excessive iron loading increases the expression of M1-associated inflammatory mediators, including IL-6, TNF-, and IL-1, while suppressing M2 markers such as transglutaminase 2 (TGM2), so efficiently guiding polarization toward the pro-inflammatory M1 phenotype (97)

Serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine show similarly favorable safety profiles in clinical practice

[97] She received the Filmfare Award for Best Actress a record-setting six times for her roles in Udta Punjab (2016), Raazi (2018), Gully Boy (2019), Gangubai Kathiawadi (2022), Rocky Aur Rani Kii Prem Kahaani (2023) and Jigra (2024), in addition to the Filmfare Critics Award for Best Actress for Highway (2014)

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