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After completion of the baseline MR scan, participants were randomly assigned in a ratio of 5:2 to either the intervention or control group using a computer-generated random-sequence allocation program

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Injection-site reactions Mild redness or swelling at the injection site is common, especially during early titration

Figure 31

Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy