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iPSC-BMEC treated with 100 nM A42 for 48 h had decreased glucose uptake, GLUT1 and GLUT3, glycolytic capacity, and glycolytic reserve

In the six simulations, the first principal component accounted for between 35% and 50% of the total variance, while none of the remaining components contributed more than 15%

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This timing has two advantages: it aligns with your body's natural growth hormone peak during slow-wave sleep, and it ensures insulin levels are low enough to avoid blunting the GH pulse