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Until recently, all actives were tested on the mushroom enzyme, but the human enzyme is of course much more complex

Figure 2 2.10 Certainty assessment The assessment was based on GRADE approach (Grading of Recommendations Assessment, Development, Evaluation): 1- Risk of Bias: The Cochrane Collaboration Risk tool was used by each author for the identified articles

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Am J Physiol Regul Integr Comp Physiol (2014) 306(5):R35262.10.1152/ajpregu.00491.2013 74 JimenezAMariACasamitjanaRLacyAFerranniniEVidalJ

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While more large-scale human studies are needed, current research and clinical use suggest that BPC-157 is well tolerated and low-risk when used under medical supervision