FBX46 Rabbit Polyclonal Antibody, 50ul Enzymes An important paralog of this

An important paralog of this gene is ZNF70

Contains 2 protein kinase domains

Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed

The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates

EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats

FBX46 Rabbit Polyclonal Antibody, 50ul Enzymes An important paralog of thisMembers of the F box protein family such as FBXO46 are characterized by an approximately 40 amino acid F box motif. SCF complexes formed by SKP1 (MIM 601434) cullin (see CUL1; MIM 603134) and F box proteins act as protein ubiquitin ligases. F box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains (Jin et al. 2004