TPP1 Polyclonal Antibody, 20ul miRNA / siRNA Synthesis and RNA splicing (Miranda et

and RNA splicing (Miranda et al

WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD)

Upon tyrosine phosphorylation

This protein has broad specificity and cleaves a variety of substrates

It has histone deacetylase activity and represses transcription when tethered to a promoter

TPP1 Polyclonal Antibody, 20ul miRNA / siRNA Synthesis and RNA splicing (Miranda etThis gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically inactive enzyme which is activated and auto proteolyzed upon acidification. Mutations in this gene result in late infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific