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FIGURE 1 3 Pharmacology and central nervous system mechanisms The therapeutic potential of semaglutide within the central nervous system (CNS) is intrinsically associated with the distribution and function of its target, the glucagon-like peptide-1 (GLP-1) receptor, as well as the drugs distinctive pharmacological properties that influence its interaction with the brain

5.5 Conclusion and future direction Recognizing the limitations of conventional delivery routes in targeting the CNS, IN administration provides a non-invasive alternative that not only bypasses the BBB but also avoids hepatic first-pass metabolism

Nicergoline also showed an improving effect on cognitive function in mouse models of Alzheimers disease [68]

Secondly, you can also combine 1-2 drops of this into your moisturiser and then apply it to your face

The rationale for this intervention is multifaceted

Parthsarathy V, Hlscher C