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Overall these results confirm that FOXO4-DRI promotes apoptosis in senescent endothelial cells by inhibiting FOXO4-P53 binding and phosphorylating P53

[DOI] [PMC free article] [PubMed] [Google Scholar] 219.Wang W, Zhang C, Zhang H, Li L, Fan T, Jin Z

Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN

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In the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC Study) [89], a treatment strategy comprising pravastatin, vitamin E and decreasing homocysteine in order to combat oxidative stress resulted in a significant decline in common carotid intima-media thickness and an improvement in brachial artery flow-mediated dilatation and urinary albumin excretion