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2022 doi: 10.5772/INTECHOPEN.104537

NICE guidance (NG28) recommends GLP-1 receptor agonists like Trulicity as a treatment option for adults with type 2 diabetes when: Triple therapy is required (in combination with metformin and another oral drug) The patient has a BMI 35 kg/m (or lower thresholds for some ethnic groups) with specific psychological or medical problems associated with obesity Insulin therapy would have significant occupational implications or weight loss would benefit other obesity-related comorbidities Importantly, NICE recommends continuing GLP-1 receptor agonist treatment only if the patient has had a beneficial metabolic response (a reduction of at least 11 mmol/mol [1.0%] in HbA1c and weight loss of at least 3% of initial body weight) after 6 months

Nerve injuries may need 8 to 12 weeks or longer

Holland, W

(9,10,11,12) How Is Neuropathic Pain Typically Treated

GLP-1s can sometimes lead to constipation, nausea, or fatigue, and proper hydration can significantly alleviate these symptoms