Rb(Phospho Thr826) Polyclonal Antibody, 20ul Buffer Solutions and the other variants encode

and the other variants encode the same protein

PTM:Sumoylated

The product of this gene functions to maintain the stability of dynein intermediate chain

Binds chylomicrons

This protein also plays a role in signal transduction pathways in the activation of T cells

Rb(Phospho Thr826) Polyclonal Antibody, 20ul Buffer Solutions and the other variants encodeThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.