PML Polyclonal Antibody, 50ul Bottles such as mitogenic activation
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PML Polyclonal Antibody, 50ul Bottles such as mitogenic activationPromyelocytic leukemia encoded by PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc binding domains, a RING, a B box type 1 and a B box type 2, and a coiled coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell cycle related and it regulates the p53 response to oncogenic signals. PML is often involved in the
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