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When stress becomes chronic, blood sugar remains elevated even without food intake

GIP and GLP-1 are naturally occurring incretin hormones that help regulate blood glucose levels

Metabolic indicators that may be associated with reduced GLP-1 activity include: Persistent elevated blood glucose levels , particularly postprandial (after-meal) hyperglycaemia Difficulty achieving or maintaining a healthy weight despite dietary efforts Increased appetite and reduced satiety after meals, leading to frequent snacking Diagnosis of type 2 diabetes or non-diabetic hyperglycaemia (NDH, sometimes called prediabetes), conditions where GLP-1 response is often blunted Features of metabolic syndrome , including central obesity, hypertension, and dyslipidaemia Individuals may also notice practical symptoms such as feeling hungry shortly after eating substantial meals, experiencing energy crashes following carbohydrate-rich foods, or finding portion control particularly challenging

Available from: MacIsaac RJ, Ekinci EI, Jerums G

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Although it came after our FY22 timeframe, the letter is worth mentioning because, in this case, the agency held the firm responsible for potentially causing downstream cGMP violations due to their inadequate testing methods