SIRT1 (GlcNAc D548) Rabbit Polyclonal Antibody, 20ul Enzymes & Activity Assays This nuclear protein interacts with

This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs

May be involved in apoptosis signaling in the presence of the reinoid CD437

SAFB and YTHDC1

process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction

a central coiled-coil region and a highly conserved carboxyl terminal domain

SIRT1 (GlcNAc D548) Rabbit Polyclonal Antibody, 20ul Enzymes & Activity Assays This nuclear protein interacts withThis gene encodes a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular